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https://repositorio-socioecologia.conahcyt.mx/jspui/handle/1000/247| Serum levels of proinflammatory cytokines in children from an agricultural community with a high risk of chronic kidney disease in Mexico | |
| Rosa Cremades González Felipe Lozano Kasten ERICK SIERRA-DIAZ | |
| Acceso Abierto | |
| Atribución-NoComercial | |
| Biomedicina | |
| OBJECTIVE: To measure serum concentrations of IL-6, IL-1β, TNF-α and MCP-1 in a pediatric population and compare them with those of persistent albuminuria and with the degree of chronic kidney disease. MATERIALS AND METHODS: Cross-sectional, longitudinal, population-based study conducted between 2016 and 2021 in participants enrolled in the Mexican Study of Albuminuria Prevalence in Children Living in a Rural Agricultural and Subsistence Com- munity Fishing Area (Agua Caliente, Jalisco). Detailed description of the participants and methodology of this study was previously reported by Lozano-Kasten, et al in 2017. RESULTS: Eighty-two children with persistent albuminuria grouped according to CKD stage based on glomerular filtration rate and KDIGO guidelines were studied. Significant differences in IL-6 concentrations were found between KDIGO G1-G3B (p = 0.02) and G3A-G3B (p = 0.02) groups, with a reduction in serum IL-6 concentrations as glomerular filtration rate decreases. In addition, urinary albumin concentration showed a trend of association with TNF-α concentrations (p = 0.09). CONCLUSION: The gradual decrease in IL-6 concentrations as CKD progresses dem- onstrates the particular immunological characteristics of the pediatric population with this disease of unknown cause. KEYWORDS: Chronic kidney disease; glomerular filtration rate; albuminuria; proinflam- matory cytokines; boys and girls. | |
| Colegio Mexicano de Urología Nacional, A.C. | |
| 2022 | |
| Artículo | |
| Inglés | |
| Estudiantes Investigadores Otros | |
| Cremades R, Sierra-Díaz E, Lozano-Kasten F, Torres Carrillo NM, Torres-Carrillo N, et al. Serum levels of proinflammatory cytokines in children from an agricultural community with a high risk of chronic kidney disease in Mexico. Bol Col Mex Urol 2022; 37: 1-13. https://doi.org/10.24245/bcmurol. v37id.7818 | |
| CIENCIAS MÉDICAS | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Appears in Collections: | Documentos |
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