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https://repositorio-socioecologia.conahcyt.mx/jspui/handle/1000/343| Frequency of Human Leukocyte Antigen Compatibility and Graft Rejection in Kidney Transplant Patients from Living Donors | |
| Diana Lorena Cisneros García ERICK SIERRA-DIAZ | |
| Acceso Abierto | |
| Atribución | |
| 10.24875/BCMU.24000027 | |
| https://www.boletinmexicanourologia.com/frame_eng.php?id=31 | |
| End-stage renal disease | |
| The aim of the present research was to identify the frequency of Human Leukocyte Antigen compatibility and graft rejection in kidney transplant patients from related donors during the period from 2019 to 2022 in one of the most important tertiary medical facilities in Mexico. Methods: A cross-sectional design was used to identify the HLA compatibility of transplanted patients registered from January 1, 2019, to December 31. The included patients were young adults aged 18-45, beneficiaries of social security provide by the government who were transplanted. Results: A total of 690 patients were transplanted during the period from 2019 to 2022. The graft survival rate was 98.67%; in just four years, a total of 9 kidney transplantectomy were performed,5 of them were transplants from unrelated relatives. Only 1 of these shared at least 2 class 1 antigens, while the rest did not share any. The related family members shared at least 1 and up to 3 class 1. In the 6-month post-transplant period, 30.25% of the patients experienced some type of renal dysfunction. Conclusion: It can be concluded that HLA compatibility is a good predictor for preventing rejection in kidney transplants from related and unrelated living donors. Efforts should be made to identify the best donor options among all future donors and explore the possibility of exchanging donors, especially unrelated living donors, among recipients on the waiting list. This is to ensure better adaptability and graft survival in patients. | |
| Colegio Mexicano de Urología | |
| 2024 | |
| Artículo | |
| Inglés | |
| Estudiantes Investigadores Otros | |
| MEDICINA Y CIENCIAS DE LA SALUD | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Appears in Collections: | Documentos |
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